Intracytoplasmic Sperm Injection (ICSI)

ICSI is a laboratory step within an IVF cycle. An embryologist selects a single sperm and injects it directly into each mature egg with a fine glass needle, instead of leaving eggs and sperm to meet in a dish.

It overcomes male factor infertility: low count, poor movement, abnormal shape, or sperm retrieved surgically from the testicle. It does not improve egg quality, and when the sperm is normal it gives no better results than standard IVF.

What Intracytoplasmic Sperm Injection (ICSI) involves

The woman goes through ordinary IVF stimulation: 9 to 12 days of hormone injections with ultrasound monitoring, a trigger injection, and egg collection under sedation 36 hours later. The same day the man gives a semen sample, or sperm is retrieved from the epididymis or testicle (PESA, TESE or micro-TESE) under anaesthetic. In the laboratory the cells surrounding each egg are removed, mature eggs are identified, and a single moving sperm is immobilised, drawn into a micropipette and injected into each egg. Fertilisation is checked the next morning. Embryos are grown for 3 to 5 days, then one is transferred and spare good embryos are frozen.

Who is a good candidate for Intracytoplasmic Sperm Injection (ICSI)?

It is recommended when sperm are unlikely to fertilise eggs unaided.

• Low sperm count, motility or normal forms on repeated semen analysis
• Azoospermia with sperm retrieved surgically
• Failed or very poor fertilisation in an earlier IVF cycle
• Use of frozen eggs or cycles with preimplantation genetic testing
• Sperm frozen before cancer treatment, in limited supply

Es ist normalerweise nicht die richtige Wahl, wenn:

• Couples with normal semen tests, for whom standard IVF works equally well
• Men with no sperm found even on micro-TESE, since donor sperm is not legal in Türkiye
• Unmarried individuals or couples, who cannot be treated under Turkish law
• Women with no usable eggs of their own, since egg donation is not permitted

Technikoptionen

• Conventional ICSI: Sperm chosen by shape and movement under high magnification.
• Micro-TESE with ICSI: Microsurgical search of the testicle for sperm in non-obstructive azoospermia.
• PESA or TESA with ICSI: Needle retrieval when the ducts are blocked, for example after vasectomy.
• Sperm selection add-ons (PICSI, IMSI, microfluidic chips): Offered for high DNA fragmentation; evidence of benefit is limited.

Was passiert während Ihrer Behandlung

The injection takes place in the laboratory and you feel nothing from it. What you experience is the IVF cycle: daily injections, 3 to 5 scans, and a 15 to 30 minute egg collection under sedation. Embryo transfer takes about 10 minutes and needs no anaesthetic. Surgical sperm retrieval takes 30 minutes to 2 hours.

Vorbereitung auf Ihre Reise

One fresh cycle needs about 15 to 20 days in Istanbul, from the start of stimulation to embryo transfer. Some couples begin injections at home with scans locally and arrive around day 6 to 8, reducing the stay to 10 to 12 days. A frozen transfer later needs 3 to 5 days.

• Informieren Sie den Arzt über Medikamente, Allergien, Schwangerschaft oder Stillen und eine Vorgeschichte von Fieberbläschen, Keloidnarben oder Autoimmunerkrankungen
• Vermeiden Sie Alkohol, Aspirin und entzündungshemmende Schmerzmittel für ein paar Tage im Voraus, wenn Ihr eigener Arzt zustimmt, um Blutergüsse zu reduzieren
• Kommen Sie ohne Make-up auf dem Behandlungsbereich an und vermeiden Sie zwei Wochen vorher Sonnenliegen und starke Sonne

Genesung und Ergebnisse

Expect bloating and mild cramps for a few days after egg collection. Most women return to normal activity the next day. After micro-TESE, men have scrotal soreness for up to a week. A pregnancy test is done 10 to 12 days after transfer. If the first transfer fails, frozen embryos can be used without repeating stimulation.

• Back to everyday activity: 1 to 2 days after egg collection
• When results show: Pregnancy test 10 to 12 days after transfer
• How long they last: One cycle; frozen embryos can be stored for later

Sicherheit, Risiken und Revisionspolitik

Most risks come from the IVF cycle rather than the injection.

• Some eggs damaged by injection, typically a few in every 100
• Failed fertilisation despite ICSI, which is uncommon
• Ovarian hyperstimulation syndrome
• Multiple pregnancy if more than one embryo is transferred
• A slightly higher rate of certain birth defects and of inherited male infertility in sons, probably linked to the underlying cause
• No sperm found at surgical retrieval

Jeder schriftliche Vorschlag wird durch Clinic-Y gibt an, was die Klinik abdeckt, wenn eine Korrektur erforderlich ist. Fragen Sie danach, bevor Sie buchen, nicht danach.

Cost of Intracytoplasmic Sperm Injection (ICSI) in Türkiye

Clinic-Y does not publish a single price for Intracytoplasmic Sperm Injection (ICSI), because the honest figure depends on your case. What moves it:

• Medication dose, which depends on age and ovarian reserve
• Whether surgical sperm retrieval is needed
• Embryo freezing, storage and later frozen transfers
• Genetic tests for the man, such as karyotype and Y-chromosome deletion

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