Ovarian Rejuvenation with PRP

Ovarian rejuvenation with platelet-rich plasma (PRP) means concentrating platelets from your own blood and injecting them into the ovaries under ultrasound guidance. The growth factors released by platelets are proposed to activate dormant follicles in women with low ovarian reserve, poor response to IVF stimulation or premature ovarian insufficiency.

This is an experimental add-on. Small, mostly uncontrolled studies report slight rises in AMH and antral follicle count and some pregnancies, but randomised trials have not shown a clear increase in live births. It cannot create new eggs or reverse egg ageing, and egg quality remains tied to your age.

What Ovarian Rejuvenation with PRP involves

Baseline tests are taken first: AMH, FSH and oestradiol early in the cycle, and an ultrasound count of antral follicles. On the day, 20 to 60 millilitres of blood are drawn and spun in a centrifuge to concentrate the platelets to several times their normal level; some kits add calcium to activate them (PRGF is one such preparation). Under sedation, as for an egg collection, a long needle attached to a vaginal ultrasound probe is passed through the vaginal wall into each ovary, and 1 to 4 millilitres of PRP are injected into the ovarian tissue in one or several spots. Hormones and follicle counts are then rechecked monthly for up to 3 months, and an IVF cycle is timed to any improvement.

Who is a good candidate for Ovarian Rejuvenation with PRP?

It may be discussed with women who have few options left and understand that the benefit is unproven.

• Women with poor ovarian response in previous IVF cycles who wish to try again with their own eggs
• Women with low AMH for their age who have been counselled about donor eggs and decline or are not ready
• Selected women with premature ovarian insufficiency who still have occasional follicle activity
• Those who accept this as a trial of treatment, preferably within a registered study

It is usually not the right choice if:

• Women after natural menopause at a typical age, where live births are extremely unlikely
• Women over about 45 hoping to improve egg quality, which PRP does not do
• Anyone with ovarian cysts of uncertain nature, a history of ovarian or hormone-sensitive cancer, or active pelvic infection
• Low platelet counts, clotting disorders or anticoagulant treatment
• Women who have not had a full fertility work-up, including the partner's semen analysis

Technique options

• Transvaginal ultrasound-guided injection: The standard route, similar to egg retrieval.
• Laparoscopic injection: Used rarely, when ovaries cannot be reached vaginally.
• Stem cell ovarian injection: Bone marrow derived cells injected into the ovary or its artery. Even less evidence than PRP; research only.
• Established alternatives: Optimised stimulation protocols, embryo banking over several cycles, and donor eggs, which give by far the highest success in low reserve.

What happens during your treatment

The procedure takes 15 to 20 minutes under intravenous sedation, plus about 30 minutes to prepare the PRP. You rest for 1 to 2 hours afterwards and go home the same day. Mild cramping and light spotting for a day are usual.

Preparing for your trip

One injection session is typical, requiring 2 to 3 days in Istanbul. Monitoring blood tests and scans over the next 1 to 3 months can be done at home and shared. If follicle numbers rise, you would return for an IVF cycle lasting about 2 weeks. Some clinics repeat the injection after 3 months if there is no response.

• Tell the doctor about medication, allergies, pregnancy or breastfeeding, and any history of cold sores, keloid scars or autoimmune disease
• Avoid alcohol, aspirin and anti-inflammatory painkillers for a few days beforehand if your own doctor agrees, to reduce bruising
• Arrive without make-up on the treatment area and avoid sunbeds and strong sun for two weeks before

Recovery and results

Rest on the day and avoid intercourse, swimming and strenuous exercise for 2 to 3 days. Any hormonal change, if it happens, tends to appear between 4 and 12 weeks after the injection and appears to fade within about 6 months, so IVF is planned within that window.

• Back to everyday activity: 1 day
• When results show: Any hormonal change at 4 to 12 weeks
• How long they last: Up to about 6 months, if at all

Safety, risks and revision policy

Because PRP comes from your own blood, reactions are unlikely; risks are those of passing a needle into the ovary.

• Pelvic pain and light vaginal bleeding
• Pelvic infection or ovarian abscess, which is rare
• Bleeding from the ovary or injury to bowel, bladder or blood vessels, as with egg collection
• Sedation-related nausea or drowsiness
• No improvement in ovarian response, which is common
• Delay in moving to treatments with a better chance, while time and age work against you

Every written proposal arranged through Clinic-Y states what the clinic covers if a correction is needed. Ask for it before you book, not after.

Cost of Ovarian Rejuvenation with PRP in Türkiye

Clinic-Y does not publish a single price for Ovarian Rejuvenation with PRP, because the honest figure depends on your case. What moves it:

• PRP preparation kit and laboratory method
• Sedation and day-unit fees
• Hormone tests and scans before and after
• Whether an IVF cycle is bundled
• Repeat injection if offered

Send your photographs or reports and you receive written, all-inclusive proposals from suitable teams, side by side. Reviewing your case is free.

Frequently Asked Questions